Publications and Presentations

Published papers:

A twin approach to unraveling epigenetics, Bell JT, Spector TD, Trends Genet, 2011 Mar: 27(3):116-25

Epigenome-wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Aging Population, Bell JT, Tsai P-C, Yang T-P, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, Shin S-Y, Dempster EL, Murray RM, Grundberg E, Hedman AK, Nica A, Small KS, The MuTHER Consortium, Dermitzakis ET, McCarthy MI, Mill J, Spector TD, Deloukas P, PLoS Genetics, April 2012, Volume 8, Issue 4

Using epigenome-wide association scans of DNA methylation in age-related complex human traits, Pei-Chien Tsai, Tim D. Spector and Jordana T. Bell, Epigenomics (2012) 4(5), 511–526

DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as a novel epigenetic biomarker, Heyn H, Carmona FJ, Gomez A, Ferreira HJ, Bell JT, Saylos S, Ward K, Stefansson OA, Moran S, Sandoval J, Eyfjord JE, Spector TD, Esteller M, Carcinogenesis, October 2012

DNA methylation studies using twins: what are they telling us?, Jordana T Bell and Tim D Spector, Genome Biol. 2012; 13(10): 172

Metabolomic markers reveal novel pathways of ageing and early development in human populations, C. Menni, G. Kastenmuller, A. K. Petersen, J. T. Bell, M. Psatha, P.-C. Tsai, C. Gieger, H. Schulz, I. Erte, S. John, M. J. Brosnan, S. G. Wilson, L. Tsaprouni, E. M. Lim, B. Stuckey, P. Deloukas, R. Mohney, K. Suhre, T. D. Spector, A. M. Valdes, Int. J. Epidemiol. 42 (4):1111-1119.

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements, Elin Grundberg, Eshwar Meduri, JohannaýK. Sandling, ýsaýK. Hedman, Sarah Keildson, Alfonso Buil, Stephan Busche, Wei Yuan, James Nisbet, Magdalena Sekowska, Alicja Wilk, Amy Barrett, Kerrin S. Small, Bing Ge, Maxime Caron, So-Youn Shin, Mark Lathrop, Emmanouil T. Dermitzakis, Mark I. McCarthy, Timothy D. Spector, Jordana T. Bell, Panos Deloukas, Cell, Volume 93, Issue 5, 7 November 2013, Pages 876–890

Glycosylation of Immunoglobulin G: Role of genetic and epigenetic influences, Menni C, Keser T, Mangino M, Bell JT, Erte I, Akmacic I, Vuckovic F, Pucic Bakovic M, Gornik O, McCarthy M, Zoldos V, Spector TD, Lauc G, Valdes AM, PLos One, December 2013 | Volume 8 | Issue 12 | e82558

Hypermethylation in the ZBTB20 gene is associated with major depressive disorder, Matthew N Davies, Lutz Krause Jordana T Bell, Fei Gao, Kirsten J Ward, Honglong Wu, Hanlin Lu, Yuan Liu, Pei-Chrien Tsai, David A Collier, Therese Murphy, Emma Dempster, Joanthon Mill, UK Brain Expression Consortium, Alexis Battle, Sara Mostafavi, Xiaowei Zhu, Anjali Henders, Edna Byrne, Naomi R Wray, Nicholas G Martin, Tim D Spector and Jun Wang, Genome Biology, 2014 Apr 2;15(4)

Differential methylation of TRPA1 promoter is associated with pain sensitivity, Bell JT, Loomis AK, Butcher LM, Gao F, Zhang B, Hyde CL, Sun J, Wu H, Ward K, Harris J, Scollen S, Davies MN, Schalkwyk LC, Mill J, The MuTHER Consortium, Williams FMK, Li N, Deloukas P, Beck S, McMahon SB, Wang J, John SL, and Spector TD, Nature Communications, 5, Article number:2978

Epigenetics of discordant monozygotic twins: implications for disease, Juan E Castillo-Fernandez, Tim D Spector, Jordana T Bell, Genome Medicine, 2014, 6:60

Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index, Clive J. Hoggart, Giulia Venturini, Massimo Mangino, Felicia Gomez, Giulia Ascari, Jing Hua Zhao, Alexander Teumer, Thomas W. Winkler, Natalia Tsernikova, Jian’an Luan, Evelin Mihailov, Georg B. Ehret, Weihua Zhang, David Lamparter, Tonu Esko, Aurelien Mace, Sina Rueger, Pierre-Yves Bochud, Matteo Barcella, Yves Dauvilliers, Beben Benyamin, David M. Evans, Caroline Hayward, Mary F. Lopez, Lude Franke, Alessia Russo, Iris M. Heid, Erika Salvi, Sailaja Vendantam, Dan E. Arking, Eric Boerwinkle, John C. Chambers, Giovanni Fiorito, Harald Grallert, Simonetta Guarrera, Georg Homuth, Jennifer E. Huffman, David Porteous, Generation Scotland Consortium, The LifeLines Cohort study, The GIANT Consortium, Darius Moradpour, Alex Iranzo, Johannes Hebebrand, John P. Kemp, Gert J. Lammers, Vincent Aubert, Markus H. Heim, Nicholas G. Martin, Grant W. Montgomery, Rosa Peraita-Adrados, Joan Santamaria, Francesco Negro, Carsten O. Schmidt, Robert A. Scott, Tim D. Spector, Konstantin Strauch, Henry Volzke, Nicholas J. Wareham, Wei Yuan, Jordana T. Bell, Aravinda Chakravarti, Jaspal S. Kooner, Annette Peters, Giuseppe Matullo, Henri Wallaschofski, John B. Whitfield, Fred Paccaud, Peter Vollenweider, Sven Bergmann, Jacques S. Beckmann, Mehdi Tafti, Nicholas D. Hastie, Daniele Cusi, Murielle Bochud, Timothy M. Frayling, Andres Metspalu, MarjoRiitta Jarvelin, Andre´ Scherag, George Davey Smith, Ingrid B. Borecki, Valentin Rousson, Joel N. Hirschhorn, Carlo Rivolta, Ruth J. F. Loos, Zolta´n Kutalik, PLoS Genetics, July 2014 | Volume 10 | Issue 7 | e1004508

Epigenome-Wide DNA Methylation in Hearing Ability: New Mechanisms for an Old Problem, Lisa E. Wolber, Claire J. Steves, Pei-Chien Tsai, Panos Deloukas, Tim D. Spector, Jordana T. Bell, Frances M. K. Williams, PLoS One. 2014 Sep 3;9(9):e105729

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation, Loukia G Tsaprouni, Tsun-Po Yang, Jordana Bell, Katherine J Dick, Stavroula Kanoni, James Nisbet, Ana Vinuela, Elin Grundberg, Christopher P Nelson, Eshwar Meduri, Alfonso Buil, Francois Cambien, Christian Hengstenberg, Jeanette Erdmann, Heribert Schunkert, Alison H Goodall, Willem H Ouwehand, Emmanouil Dermitzakis, Tim D Spector, Nilesh J Samani, Panos Deloukas, Epigenetics, 2014;9(10):1382-96

Obesity accelerates epigenetic aging of human liver, S. Horvath, W. Erhart, M. Brosch, O. Ammerpohl, W. von Schonfels, M. Ahrens, N. Heits, J. T. Bell, P.-C. Tsai, T. D. Spector, P. Deloukas, R. Siebert, B. Sipos, T. Becker, C. Rocken, C. Schafmayer, J. Hampe, PNAS, October 28, 2014, volume 111, number 43, pages 15538–15543

An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins, Wei Yuan, Yudong Xia, Christopher G. Bell, Idil Yet, Teresa Ferreira, Kirsten J. Ward, Fei Gao, A. Katrina Loomis, Craig L. Hyde, Honglong Wu, Hanlin Lu, Yuan Liu, Kerrin S. Small, Ana Vinuela, Andrew P. Morris, Marýa Berdasco, Manel Esteller, M. Julia Brosnan, Panos Deloukas, Mark I. McCarthy, Sally L. John, Jordana T. Bell, Jun Wang, Tim D. Spector, Nature Communications, 5, Article number:5719

 

 

Scientific Presentations:

Epitwin Background Presentation - EpiTwin background presentation

SNPs and Human Complex Disease, Erasmus EMC in Rotterdam, 15th November 2010 - "Twin Studies"

Epigenomics of common disease conference, Cambridge UK, September 2011 - The Epitwin Project

Epigenome of common disease conference, Cambridge UK, September 2011 - "Identifying ageing-related differentially methylated regions in twins"

Epigenomics of common disease conference, Cambridge UK, September 2011 - "Use of twins in Epigenomics of Common Diseases"

American Society of Human Genetics, Montreal Canada, October 2011 - "Genome-wide MeDIP-sequencing profiles identify differentially methylated regions in monozygotic twins discordant for pain sensitivity"

Next Generation Sequencing Congress, London UK, Novermber 2011 - "Use of Twins in Complex Trait Epigenomics"

SNPs and Human Complex Disease, Erasmus EMC in Rotterdam, 21st November 2011 - "Twin Studies"

14th Congress of the International Society for Twin Studies, Florence Italy, April 2012 - "Epigenetics of pain"

TreatOA meeting, London UK - "Epigenetic modifications in ageing and age-related disease"

American Society for Human Genetics, 2011 - "Genome-wide MeDIP-sequencing profiles identify differentially methylated regions in monozygotic twins discordant for pain sensitivity"

Next Generation Sequencing Congress, 2011 - "Use of Twins in Complex Trait Epigenomics"

14th congress of the international society for twin studies (ISTS) in florence, April 1-4th 2012 - "Epigenetics of pain"

TreatOA, Royal College of Physicians, London, April 12th 2012– "Epigenetic modifications in ageing and age-related disease"

International Conference on Genomics in Europe, Copenhagen Denmark, May 2012 - "Large Scale epigenomics for common diseases - The EpiTwin Study"

CSC Symposium: Epigenetic Regulation: From Mechanisms to Intervention, London UK, June 2012 - "Large Scale Epigenomics of Common Disease"

World Epigenetics Summit, Boston USA, July 2012 - "Relating Epigenetic Changes to Indications: Prospects for Diagnosis, Drug Targets and Personalized Medicine"

Epigenomics of Common Diseases, Johns Hopkins University, Baltimore, USA, October 2012 - "A twin study of DNA methylation profiles in whole blood"

Epigenomics of Common Disease, John Hopkins University, Baltimore, USA, October 2012 - "DNA methylation effects in Type 2 diabetes: an epigenome-wide association twin study "

Oslo Epigenetics Symposium, Oslo Norway, November 2012 - "Large Scale Epigenomics for Common Disease: EpiTwin Study"

SNPs and Human Complex Disease, Erasmus EMC in Rotterdam, 19th November 2012 - "Twin Studies"

American Society of HUman Genetics, Boston USA, October 2013 - "Predicting genome-wide DNA methylation using methylation marks, genomic positions and DNA regulatory elements"

Epigenomics of Common Disease Conference, Cambridge UK, November 2013 - "Genetic influences of DNA methylation levels and variance in twins"

Epigenomics of Common Disease Conference, Cambridge UK, November 2013 - "A genome-wide DNA methylation screen in cancer discordant identical twins"

Progress Educational Trust Conference: "Double Take: Twins in Genetics and Fertility Treatment", London UK, December 2013 - "Identically Different: Twins and Epigenetics"

Northern Epigenomics Club meeting, Manchester UK, April 2014 - "Epigenomie-wide association scans: an application to pain sensitivity"

British Society for Investigative Dermatology meeting, April 2014 - "Epigenetics of skin ageing"

Genomics of gene expression and ageing conference, May 2014 - "Epigenetics and ageing in twins"

Academia Sincia, Taiwan, June 2014 - "Epigenome-wide Association Scans (EWAS) Identify DNA Methylation Changes in the THADA Gene amoung Adult Birth Weight Discordant Monozygotic Twin Pairs"

3rd ACTTION Scientific Workshop: Transformative Strategies for the Devlopment of New Pain Therapies, June 2014 - "DNA Methylation studies in twins"

EBI, Hinxton UK, August 2014 - "Epigenetic profiling of human populations"

EurHealth Summer School, London UK, September 2014 - "Epigenetic studies in twins"

American Society of Human Genetics, San Diego UK, October 2014 - "Genome-wide association scans identify differentially methylated and expressed regions related to smoking in adipose tissue"

Epigenomics of Common Disease Conference, Cambridge UK, October 2014 - "Genetic and environmental impacts on DNA methylation across tissues in twins"

Epigenomics of Common Disease Conference, Cambridge UK, October 2014 - "Epigenome-wide effects of thyroid peroxidase antibodies"

Epigenomics of Common Disease Conference, Cambridge UK, October 2014 - "Genetic influences of DNA methylation levels and variance in twins using multiple tissues"

Epigenomics of Common Disease Conference, Cambridge UK, October 2014 - "The effect of invitro fertilisation on epigenetic profiles"

Epigenomics of Common Disease Conference, Cambridge UK, October 2014 - "Epigenome-wide association scan in healthy human skin tissue in relation to total body naevus counts"

15th International Congress of Twin Studies, Budapest Hungary, November 2014 - "Characterizing DNA methylation heritability across the genome"

15th International Congress of Twin Studies - Pre-congress course in "Epigenetics and Twinning", Budapest Hungary, November 2014 - "Characterizing DNA methylation heritability across the genome"

15th International Congress of Twin Studies, Budapest Hungary, November 2014 - "A blood DNA methylation biomarker study for cancer using identical twins"

PhD Thesis Viva, London UK, December 2014 - "Epigenetic Determinants of Healthy Ageing and Age-related Disease Risk"

 

 

Dissemination outside of the scientific community:

Midlands Twin Party, Northampton UK, September 2011 - "Epigenetics in twins"

Youtube video, London UK, May 2012 - "Epigenetics"

Words by the Water, Keswick UK, March 2013 - "Identically Different"

National Twin Day, Kettering UK, September 2014 - "The TwinsUK Cohort"